As we all know, emacs is the One True Editor. And, if you've used it, you know that you spend lots of time holding down the CTRL key. Many hard-core Mac/emacs users have re-wired the CAPS-LOCK key (which is useless anyway) to be another control key, saving wear and tear on the wrist and little finger of the left hand. (This by the way can be accomplished in the Keyboard preferences pane.)
The other day I accidentally used the emacs "down one line" command (CTRL-N) while using Quicksilver to navigate the file system...and it worked! Now, I use CTRL-P (up one line) and CTRL-N all the time because it's easier when typing to not have to move to the arrow keys.
Quicksilver: wysiwyg asap